Anti-ACTH (Phospho-Ser168) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:DB

Purify method:Affinity purified

Species:Human

Gene Name:acth

Synonyms:Pro-opiomelanocortin, POMC, Corticotropin-lipotropin, NPP, Melanotropin gamma, Gamma-MSH, Potential peptide, Corticotropin, Adrenocorticotropic hormone, ACTH, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin, POMC

Gene Synonyms:

Gene Full Name:

Gene Infomation:This gene encodes a polypeptide hormone precursor thatundergoes extensive, tissue-specific, post-translational processingvia cleavage by subtilisin-like enzymes known as prohormoneconvertases. There are eight potential cleavage sites within thepolypeptide precursor and, depending on tissue type and theavailable convertases, processing may yield as many as tenbiologically active peptides involved in diverse cellularfunctions. The encoded protein is synthesized mainly incorticotroph cells of the anterior pituitary where four cleavagesites are used; adrenocorticotrophin, essential for normalsteroidogenesis and the maintenance of normal adrenal weight, andlipotropin beta are the major end products. In other tissues,including the hypothalamus, placenta, and epithelium, all cleavagesites may be used, giving rise to peptides with roles in pain andenergy homeostasis, melanocyte stimulation, and immune modulation.These include several distinct melanotropins, lipotropins, andendorphins that are contained within the adrenocorticotrophin andbeta-lipotropin peptides. Mutations in this gene have beenassociated with early onset obesity, adrenal insufficiency, and redhair pigmentation. Alternatively spliced transcript variantsencoding the same protein have been described. [provided byRefSeq].

Antigen:This ACTH Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S168 of human ACTH.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:RB16586

Dilution:Other::DB:1:500

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Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

Background:

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Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.