Anti-ARHGEF3 (Center) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:WB,IHC-P

Purify method:Affinity purified

Species:Human

Gene Name:arhgef3

Synonyms:Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3

Gene Synonyms:

Gene Full Name:

Gene Infomation:Rho-like GTPases are involved in a variety of cellularprocesses, and they are activated by binding GTP and inactivated byconversion of GTP to GDP by their intrinsic GTPase activity.Guanine nucleotide exchange factors (GEFs) accelerate the GTPaseactivity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, whichspecifically activates two members of the Rho GTPase family: RHOAand RHOB, both of which have a role in bone cell biology. It hasbeen identified that genetic variation in this gene plays a role inthe determination of bone mineral density (BMD), indicating theimplication of this gene in postmenopausal osteoporosis.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.

Antigen:This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:RB27451

Dilution:WB::1:1000IHC::1:50~100

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Tissue specificity:

Storage:

Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

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Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.