Anti-BCL2L1 Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:IgG

Host:Rabbit

Application:WB

Purify method:Affinity purified

Species:Human,Mouse,Rat

Gene Name:bcl2l1

Synonyms:Apoptosis regulator Bcl X;Apoptosis regulator Bcl X;Apoptosis regulator Bcl-X;Apoptosis regulator BclX;B cell lymphoma 2 like;B2CL1_HUMAN;Bcl 2 like 1;Bcl 2 like 1 protein;Bcl X;Bcl xL;Bcl xL;BCL XL/S;Bcl xS;Bcl xS;Bcl-2-like protein 1;Bcl2 Like 1;Bcl2 like1;Bcl2 like1;Bcl2 related gene;Bcl2-L-1;BCL2L;BCL2L1;BCL2L1;Bclx;BclXL;BclXs;DKFZp781P2092; PPP1R52;Protein phosphatase 1 regulatory subunit 52.

Gene Synonyms:BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S

Gene Full Name:

Gene Infomation:The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]

Antigen:Peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:Human

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB::1:300Other::1:1000

Mole Mass:30

Location:Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm ? cytoskeleton ? centrosome. Note: Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phospho

Concentration:1mg/ml

Sequence Similarity:Belongs to the Bcl-2 family.

Gene Id:598

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:The antibody detects endogenous level of total BCL2L1 protein.

Storage:

Buffer condition:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.