Anti-BRCA1 (N-term) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:WB

Purify method:Affinity purified

Species:Human

Gene Name:

Synonyms:Breast cancer type 1 susceptibility protein, 632-, RING finger protein 53, BRCA1, RNF53

Gene Synonyms:

Gene Full Name:

Gene Infomation:This gene encodes a nuclear phosphoprotein that plays arole in maintaining genomic stability, and it also acts as a tumorsuppressor. The encoded protein combines with other tumorsuppressors, DNA damage sensors, and signal transducers to form alarge multi-subunit protein complex known as the BRCA1-associatedgenome surveillance complex (BASC). This gene product associateswith RNA polymerase II, and through the C-terminal domain, alsointeracts with histone deacetylase complexes. This protein thusplays a role in transcription, DNA repair of double-strandedbreaks, and recombination. Mutations in this gene are responsiblefor approximately 40% of inherited breast cancers and more than 80%of inherited breast and ovarian cancers. Alternative splicing playsa role in modulating the subcellular localization and physiologicalfunction of this gene. Many alternatively spliced transcriptvariants, some of which are disease-associated mutations, have beendescribed for this gene, but the full-length natures of only someof these variants has been described. A related pseudogene, whichis also located on chromosome 17, has been identified. [provided byRefSeq].

Antigen:This BRCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-472 amino acids from the N-terminal region of human BRCA1.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB::1:1000

Mole Mass:

Location:

Concentration:

Sequence Similarity:

Gene Id:

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:

Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.