Anti-CaMK2-a(Phospho-Thr286) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:IgG

Host:Rabbit

Application:WB,IHC

Purify method:Affinity purified

Species:Human,Mouse,Rat

Gene Name:camk2a

Synonyms:alpha CaMKII;Calcium / Calmodulin Dependent Protein Kinase II G;Calcium / Calmodulin Dependent Protein Kinase II G;Calcium calmodulin dependent protein kinase CaM kinase II alpha;Calcium calmodulin dependent protein kinase II alpha-B subunit;Calcium calmodulin dependent protein kinase II;Calcium calmodulin dependent protein kinase type II alpha chain;Calcium calmodulin dependent protein kinase type II beta chain;Calcium/calmodulin dependent protein kinase II alpha;Calcium/calmodulin dependent protein kinase II alpha B subunit;Calcium/calmodulin dependent protein kinase type II alpha chain;Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;Calcium/calmodulin-dependent protein kinase II alpha;Calcium/calmodulin-dependent protein kinase II-alpha;Calcium/calmodulin-dependent protein kinase type II subunit alpha;Calcium/calmodulin-dependent protein kinase type IIA;CaM kinase II alpha chain;CaM kinase II alpha subunit;CaM kinase II beta chain;CaM kinase II beta subunit;CaM kinase II delta chain;CaM kinase II delta subunit;CaM kinase II subunit alpha;CAM2;CaMK II alpha subunit;CaMK II beta subunit;CaMK II delta subunit;CaMK-II subunit alpha;Camk2a;CAMK2B;CAMK2D;CAMKA;CAMKB;CaMKII;CaMKIINalpha;EC 2.7.11.17;KCC2A_HUMAN;KIAA0968;MGC123320;MGC139375;MGC155201;mKIAA0968;PK2CDDPKCCD;Proline rich calmodulin dependent protein kinase;R74975;zgc:112538;zgc:123320.

Gene Synonyms:CAMKA

Gene Full Name:

Gene Infomation:The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

Antigen:The antiserum was produced against synthesized phosphopeptide derived from human CaMK2-a around the phosphorylation site of threonine 286 (Q-E-TP-V-D).

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:Human

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:

Mole Mass:54

Location:Cell junction › synapse › presynaptic cell membrane. Cell junction › synapse. Note: Postsynaptic lipid rafts.

Concentration:

Sequence Similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Contains 1 protein kinase domain.

Gene Id:815

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:This antibody detects endogenous levels of CaMKII alpha and does not cross-react with related proteins.

Storage:

Buffer condition:10mM PBS with 0.02% sodium azide, 50% glycerol.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.