Anti-FGFR1(Phospho-Tyr154) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:IgG

Host:Rabbit

Application:WB,IHC

Purify method:Affinity purified

Species:Human

Gene Name:fgfr1

Synonyms:Basic fibroblast growth factor receptor 1;Basic fibroblast growth factor receptor 1;bFGF R;bFGF R;bFGF-R-1;BFGFR;C FGR;C FGR;CD 331;CD331;CD331 antigen;CEK;CEK;FGFBR;FGFBR;FGFR 1;FGFR 1;FGFR-1;FGFR1;FGFR1_HUMAN;Fibroblast growth factor receptor 1;FLG;FLG protein;FLG protein;FLJ14326;FLJ14326;FLT 2;FLT 2;FLT-2;FLT2;FMS like tyrosine kinase 2;Fms like tyrosine kinase 2;Fms related tyrosine kinase 2;Fms related tyrosine kinase 2;Fms related tyrosine kinase 2 Pfeiffer syndrome;Fms-like tyrosine kinase 2;H2;H2;H3;H3;H4;H4;H5;H5;HBGFR;Heparin binding growth factor receptor;Heparin binding growth factor receptor;Hydroxyaryl protein kinase;Hydroxyaryl protein kinase;KAL 2;KAL 2;KAL2;MFR;MFR;N SAM;N sam tyrosine kinase;N sam tyrosine kinase;Protein tyrosine kinase;Protein tyrosine kinase;Proto-oncogene c-Fgr;Tyrosylprotein kinase;Tyrosylprotein kinase.

Gene Synonyms:CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1

Gene Full Name:

Gene Infomation:The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Antigen:The antiserum was produced against synthesized phosphopeptide derived from human FGFR1 around the phosphorylation site of tyrosine 154 (A-P-YP-W-T).

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:Human

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:

Mole Mass:92

Location:Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm › cytosol. Cytoplasmic vesicle. Note: After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation

Concentration:

Sequence Similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

Gene Id:2260

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:This antibody detects endogenous levels of FGFR1 and does not cross-react with related proteins.

Storage:

Buffer condition:10mM PBS with 0.02% sodium azide, 50% glycerol.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.