Anti-HDAC11 Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:Rabbit IgG

Host:Rabbit

Application:WB,IP

Purify method:Affinity Chromatography

Species:Human

Gene Name:

Synonyms:HDAC11; HD11; Histone deacetylase 11;

Gene Synonyms:

Gene Full Name:

Gene Infomation:Histone deacetylases (HDACs) play an important role in the modification of chromatin structure and thus in the suppression and activation of transcription and cellular differentiation. There are 11 members in the HDAC family that are classified into four classes. Class I HDACs represent homologs of the yeast histone deacetylase RPD3, class II HDACs share strong homology with the yeast histone deacetylase HDA1, class III HDAC are closely related to the yeast SIR2 protein, and class IV HDACs comprises Histone deacetylase 11 (HDAC11)-related enzymes. HDAC11 contains 347 amino acid residues. HDAC11 contains conserved residues in the catalytic core regions shared by both class I and II mammalian HDAC enzymes. Expression of HDAC11 is high in the kidney, heart, brain, skeletal muscle, and testis, and it localizes to the cell nucleus. The human gene encoding for HDAC11 maps to chromosome 3p25.

Antigen:A synthesized peptide derived from human HDAC11

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:

Reaction:HDAC11 Antibody detects endogenous levels of total HDAC11

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB 1:1000~1:2000 IP 1:50

Mole Mass:39kDa

Location:Nucleus;

Concentration:

Sequence Similarity:Belongs to the histone deacetylase family.

Gene Id:

SwissProt ID:Q96DB2

Unigene:

Nucleotide Accession:

Tissue specificity:HDAC11 Antibody detects endogenous levels of total HDAC11

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Background:play an important role in the modification of chromatin structure and thus in the suppression and activation of transcription and cellular differentiation. There are 11 members in the HDAC family that are classified into four classes. Class I HDACs represent homologs of the yeast histone deacetylase RPD3, class II HDACs share strong homology with the yeast histone deacetylase HDA1, class III HDAC are closely related to the yeast SIR2 protein, and class IV HDACs comprises Histone deacetylase 11 (HDAC11)-related enzymes. HDAC11 contains 347 amino acid residues.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.