Anti-HDAC6 Mouse mAb
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Antibody type:Primary antibody
Label:Unconjugated
Modification:Unmodification
Isotype:IgG2a
Host:Mouse
Application:WB
Purify method:Affinity purified
Species:Human
Gene Name:HDAC6
Synonyms:HD6;JM21;CPBHM;PPP1R90;HDAC6
Gene Synonyms:FLJ16239 ;HD 6 ;HD6 ;HDAC 6 ;HDAC6 ;HDAC6_HUMAN ;Histone deacetylase 6 (HD6) ;Histone deacetylase 6 ;JM 21 ;JM21 ;KIAA0901 ;OTTHUMP00000032398 ;OTTHUMP00000197663
Gene Full Name:
Gene Infomation:
Antigen:Purified recombinant human HDAC6 protein expressed in E.coli.
Antigen Synonyms:
Clonality:Monclonal antibody
Source:
Reaction:This antibody detects endogenous levels ofHDAC6 and does not cross-react with related proteins.
Form:Liquid
Tested Applications:
- Western blot (1:100 to 1:500)
- Immunofluorescence (1:50 to 1:400)
- Immunohistochemistry (1:200 to 1:500)
- Flow cytometry analysis (1:200 to 1:500)
- Enzyme-linked Immunosorbent Assay (1:100-1:5000)
Clone:3B2-F5-G6
Dilution:WB 1:1000
Mole Mass:160kDa
Location:Nucleus._x000D_Cytoplasm._x000D_Perikaryon._x000D_Cell projection › dendrite._x000D_Cell projection › axon.
Concentration:1.75mg/ml
Sequence Similarity:Belongs to the histone deacetylase family. HD type 2 subfamily._x000D_Contains 1 UBP-type zinc finger.
Gene Id:10013
SwissProt ID:Q9UBN7
Unigene:
Nucleotide Accession:
Tissue specificity:
Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Buffer condition:Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Background:Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
Molar Function:
Western Blot:Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.