Anti-HER2/ErbB2 Mouse mAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:IgG1

Host:Mouse

Application:WB

Purify method:Affinity purified

Species:Transfected

Gene Name:erbb2

Synonyms:NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Gene Synonyms:Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;C erb B2/neu protein;CD340;CD340 antigen;Cerb B2/neu protein;CerbB2;Erb b2 receptor tyrosine kinase 2;ERBB2;ERBB2_HUMAN;HER 2;HER 2/NEU;HER2;Herstatin;Hu

Gene Full Name:

Gene Infomation:

Antigen:Purified recombinant human HER2/ErbB2 protein fragments expressed in E.coli.

Antigen Synonyms:

Clonality:Monclonal antibody

Source:Human

Reaction:Transfected Only.

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:5B6-A9-C8

Dilution:WB 1:1000

Mole Mass:138kDa

Location:EndoIsoform 1 :_x000D_Cell membrane; Single-pass type I membrane protein_x000D_Cytoplasm › perinuclear region_x000D_Nucleus_x000D_Note: Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1._x000D_Isoform 2 :_x000D_Cytop

Concentration:2.87mg/ml

Sequence Similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily._x000D_Contains 1 protein kinase domain.

Gene Id:2064

SwissProt ID:P04626

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

Background:This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.