Anti-HLA-DRB4 (N-term) Rabbit pAb
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Antibody type:Primary antibody
Label:Unconjugated
Modification:
Isotype:Rabbit Ig
Host:Rabbit
Application:WB
Purify method:Affinity purified
Species:Human
Gene Name:hla-drb4
Synonyms:HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4
Gene Synonyms:
Gene Full Name:
Gene Infomation:HLA-DRB4 belongs to the HLA class II beta chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DRA) and a beta (DRB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The beta chain isapproximately 26-28 kDa and its gene contains 6 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andexon 5 encodes the cytoplasmic tail. Within the DR molecule thebeta chain contains all the polymorphisms specifying the peptidebinding specificities. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. DRB1 is expressedat a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB4 is linked with allelic variants of DRB1,otherwise it is omitted. There are 4 related pseudogenes: DRB2,DRB6, DRB7, DRB8 and DRB9.
Antigen:This HLA-DRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human HLA-DRB4.
Antigen Synonyms:
Clonality:Polyclonal antibody
Source:HUMAN
Reaction:
Form:Liquid
Tested Applications:
- Western blot (1:100 to 1:500)
- Immunofluorescence (1:50 to 1:400)
- Immunohistochemistry (1:200 to 1:500)
- Flow cytometry analysis (1:200 to 1:500)
- Enzyme-linked Immunosorbent Assay (1:100-1:5000)
Clone:RB33594
Dilution:WB::1:1000
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Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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Molar Function:
Western Blot:Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.