Anti-IKKa/b(Phospho-Ser180/181) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:IgG

Host:Rabbit

Application:IHC

Purify method:Affinity purified

Species:Human,Mouse,Rat

Gene Name:ikka/b

Synonyms:chuk;CHUK1;Conserved Helix Loop Helix Ubiquitous Kinase;Conserved helix loop ubiquitous kinase;Conserved helix-loop-helix ubiquitous kinase;I Kappa B Kinase 1;I Kappa B Kinase Alpha;I-kappa-B kinase 1;I-kappa-B kinase alpha;IkappaB kinase;IkB kinase alpha subunit;IKBKA;IKK 1;IKK A;IKK a kinase;IKK-A;IKK-alpha;IKK1;IKKA;IKKA_HUMAN;Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells;Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit;Inhibitor of nuclear factor kappa-B kinase subunit alpha;NFKBIKA;Nuclear Factor Kappa B Inhibitor Kinase Alpha;Nuclear factor NF kappa B inhibitor kinase alpha;Nuclear factor NF-kappa-B inhibitor kinase alpha;Nuclear factor NFkappaB inhibitor kinase alpha;Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor;TCF-16;TCF16;Transcription factor 16. / I kappa B kinase 2;I kappa B kinase beta;I-kappa-B kinase 2;I-kappa-B-kinase beta;IkBKB;IKK 2;IKK B;IKK beta;IKK-B;IKK-beta;IKK2;IKKB;IKKB_HUMAN;Inhibitor of kappa light chain gene enhancer in B cells;Inhibitor of kappa light polypeptide gene enhancer in B cells;Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta;Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta;Inhibitor of nuclear factor kappa B kinase beta subunit;Inhibitor of nuclear factor kappa B kinase subunit beta;Inhibitor of nuclear factor kappa-B kinase subunit beta;MGC131801;NFKBIKB;Nuclear factor NF kappa B inhibitor kinase beta;Nuclear factor NF-kappa-B inhibitor kinase beta;Nuclear factor of kappa light chain gene enhancer in B cells inhibitor.

Gene Synonyms:IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha /IKK2; IKKB; IMD15; NFKBIKB; IKK-beta

Gene Full Name:

Gene Infomation:This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]/The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

Antigen:The antiserum was produced against synthesized phosphopeptide derived from human IKKa/b around the phosphorylation site of serine 180/181 (C-T-SP-F-V ).

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:Human

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:

Mole Mass:84/87

Location:Cytoplasm. Nucleus. Note: Shuttles between the cytoplasm and the nucleus./Cytoplasm. Nucleus. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.

Concentration:

Sequence Similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain.

Gene Id:1147,3551

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:This antibody detects endogenous levels of IKKa/b protein.

Storage:

Buffer condition:10mM PBS with 0.02% sodium azide, 50% glycerol.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.