Anti-KMT4 / Dot1LRabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:Rabbit IgG

Host:Rabbit

Application:WB

Purify method:Affinity Chromatography

Species:Human,Mouse

Gene Name:

Synonyms:DOT 1; DOT1L; KMT4; Histone methyltransferase DOT1L; H3 lysine-79 specific;

Gene Synonyms:

Gene Full Name:

Gene Infomation:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Antigen:A synthesized peptide derived from human KMT4 / Dot1L

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:

Reaction:KMT4 / Dot1L Antibodydetects endogenous levels of total KMT4 / Dot1L

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB 1:500~1:3000

Mole Mass:185kDa

Location:Nucleus;

Concentration:

Sequence Similarity:Contains 1 bZIP (basic-leucine zipper) domain.

Gene Id:

SwissProt ID:Q8TEK3

Unigene:

Nucleotide Accession:

Tissue specificity:KMT4 / Dot1L Antibodydetects endogenous levels of total KMT4 / Dot1L

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Background:Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.