Anti-MC1R (Center) Mouse mAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:IgM

Host:Mouse

Application:WB

Purify method:Affinity purified

Species:Human

Gene Name:mc1r

Synonyms:Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR

Gene Synonyms:

Gene Full Name:

Gene Infomation:This intronless gene encodes the receptor protein formelanocyte-stimulating hormone (MSH). The encoded protein, a sevenpass transmembrane G protein coupled receptor, controlsmelanogenesis. Two types of melanin exist: red pheomelanin andblack eumelanin. Gene mutations that lead to a loss in function areassociated with increased pheomelanin production, which leads tolighter skin and hair color. Eumelanin is photoprotective butpheomelanin may contribute to UV-induced skin damage by generatingfree radicals upon UV radiation. Binding of MSH to its receptoractivates the receptor and stimulates eumelanin synthesis. Thisreceptor is a major determining factor in sun sensitivity and is agenetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skinand hair color, providing evidence that this gene is an importantcomponent in determining normal human pigment variation. [providedby RefSeq].

Antigen:This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.

Antigen Synonyms:

Clonality:Monclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:578CT6.2.3

Dilution:WB::1:100~250

Mole Mass:

Location:

Concentration:

Sequence Similarity:

Gene Id:

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:

Buffer condition:Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.