Anti-MEKK2 Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:Rabbit IgG

Host:Rabbit

Application:WB,IHC,ICC/IF,IP,FC

Purify method:Affinity Chromatography

Species:Human,Mouse,Rat

Gene Name:

Synonyms:MAP3K2; MAP/ERK kinase kinase 2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B;

Gene Synonyms:

Gene Full Name:

Gene Infomation:Cyclin H belongs to a conserved cyclin family that plays a critical role in the regulation of cell cycle dependent kinases (CDKs) necessary for cell cycle progression (1,2). In general, the activity of CDKs requires the binding of appropriate cyclins as well as phosphorylation driven by Cdk-activating kinase (CAK). Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Antigen:A synthesized peptide derived from human MEKK2

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:

Reaction:MEKK2 Antibody detects endogenous levels of MEKK2

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30 FC 1:50

Mole Mass:70kDa

Location:

Concentration:

Sequence Similarity:

Gene Id:

SwissProt ID:Q9Y2U5

Unigene:

Nucleotide Accession:

Tissue specificity:MEKK2 Antibody detects endogenous levels of MEKK2

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Background:The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates the kinases involved in the MAP kinase signaling pathway including MAPK7 and MAP2K4. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases (IKKs), and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2 (PRKCL2/PRK2), which suggests its involvement in PRKCL2 regulated signaling process.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.