Anti-NOTCH3 (C-term Q2306) Mouse mAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:IgG1

Host:Mouse

Application:WB

Purify method:Affinity purified

Species:Human

Gene Name:notch3

Synonyms:Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3

Gene Synonyms:

Gene Full Name:

Gene Infomation:This gene encodes the third discovered human homologue ofthe Drosophilia melanogaster type I membrane protein notch. InDrosophilia, notch interaction with its cell-bound ligands (delta,serrate) establishes an intercellular signalling pathway that playsa key role in neural development. Homologues of the notch-ligandshave also been identified in human, but precise interactionsbetween these ligands and the human notch homologues remains to bedetermined. Mutations in NOTCH3 have been identified as theunderlying cause of cerebral autosomal dominant arteriopathy withsubcortical infarcts and leukoencephalopathy (CADASIL). [providedby RefSeq].

Antigen:This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.

Antigen Synonyms:

Clonality:Monclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:487CT6.9.2

Dilution:WB::1:2000

Mole Mass:

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Sequence Similarity:

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SwissProt ID:

Unigene:

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Tissue specificity:

Storage:

Buffer condition:Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.