Anti-PCBP1 (Center) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:WB

Purify method:Affinity purified

Species:Human,Mouse

Gene Name:pcbp1

Synonyms:Poly(rC)-binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB23, PCBP1

Gene Synonyms:

Gene Full Name:

Gene Infomation:This intronless gene is thought to have been generated byretrotransposition of a fully processed PCBP-2 mRNA. This gene andPCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to havearisen as a result of duplication events of entire genes. Theprotein encoded by this gene appears to be multifunctional. Italong with PCBP-2 and hnRNPK corresponds to the major cellularpoly(rC)-binding protein. It contains three K-homologous (KH)domains which may be involved in RNA binding. This encoded proteintogether with PCBP-2 also functions as translational coactivatorsof poliovirus RNA via a sequence-specific interaction withstem-loop IV of the IRES and promote poliovirus RNA replication bybinding to its 5'-terminal cloverleaf structure. It has also beenimplicated in translational control of the 15-lipoxygenase mRNA,human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.The encoded protein is also suggested to play a part in formationof a sequence-specific alpha-globin mRNP complex which isassociated with alpha-globin mRNA stability.

Antigen:This PCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the Central region of human PCBP1.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:RB39472

Dilution:WB::1:2000

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Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

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Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.