Anti-PDP1 (Center) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:IHC-P,WB

Purify method:Affinity purified

Species:Human,Rat

Gene Name:pdp1

Synonyms:[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial, PDP 1, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PDPC 1, PDP1, PDP, PPM2C

Gene Synonyms:

Gene Full Name:

Gene Infomation:Pyruvate dehydrogenase (E1) is one of the three components(E1, E2, and E3) of the large pyruvate dehydrogenase complex.Pyruvate dehydrogenase kinases catalyze phosphorylation of serineresidues of E1 to inactivate the E1 component and inhibit thecomplex. Pyruvate dehydrogenase phosphatases catalyze thedephosphorylation and activation of the E1 component to reverse theeffects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenasephosphatase is a heterodimer consisting of catalytic and regulatorysubunits. Two catalytic subunits have been reported; one ispredominantly expressed in skeletal muscle and another one is ismuch more abundant in the liver. The catalytic subunit, encoded bythis gene, is the former, and belongs to the protein phosphatase 2C(PP2C) superfamily. Along with the pyruvate dehydrogenase complexand pyruvate dehydrogenase kinases, this enzyme is located in themitochondrial matrix. Mutation in this gene causes pyruvatedehydrogenase phosphatase deficiency. Multiple alternativelyspliced transcript variants encoding different isoforms have beenidentified.

Antigen:This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:RB31327

Dilution:WB::1:2000IHC::1:10~50

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Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

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Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.