Anti-Phospho-Chk2 (Thr68) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Phosphoralated

Isotype:Rabbit IgG

Host:Rabbit

Application:WB

Purify method:Affinity purified

Species:Human

Gene Name:chk2

Synonyms:CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

Gene Synonyms:CDS 1;Cds1;Cds1 homolog;Checkpoint kinase 2;Checkpoint like protein CHK2;CHEK 2;Chek2;Chk 2;CHK2 checkpoint homolog (S. pombe);CHK2 checkpoint homolog;CHK2_HUMAN;hCds1;HuCds 1;LFS 2;LFS2;PP1425;RAD 53;RAD53;Rad53 homolog;Serine/threonine protein kinase Ch

Gene Full Name:

Gene Infomation:

Antigen:CSLETVSp-TQELYSI

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB 1:1000

Mole Mass:62kDa

Location:Isoform 2 :_x000D_Nucleus_x000D_Isoform 4 :_x000D_Nucleus_x000D_Isoform 7 :_x000D_Nucleus_x000D_Isoform 9 :_x000D_Nucleus_x000D_Isoform 12 :_x000D_Nucleus_x000D_Nucleus › PML body_x000D_Nucleus › nucleoplasm

Concentration:

Sequence Similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily._x000D_Contains 1 FHA domain._x000D_Contains 1 protein kinase domain.

Gene Id:11200

SwissProt ID:O96017

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:10mM PBS with 0.02% sodium azide 50% glycerol.

Background:These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.