Anti-Phospho-JAK2 (Y1007 + Y1008) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:Rabbit IgG

Host:Rabbit

Application:WB,IHC,ICC,IP,FC

Purify method:Affinity Chromatography

Species:Human

Gene Name:

Synonyms:EC 2.7.10.2; JAK-2; JAK2; Janus kinase 2; kinase Jak2;

Gene Synonyms:

Gene Full Name:

Gene Infomation:Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neuronal defects and embryonic lethality (2,3). Loss of WASP results in immune system defects and fewer immune cells (4).

Antigen:A synthesized peptide derived from human Phospho-JAK2 (Y1007 + Y1008)

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:

Reaction:Phospho-JAK2 (Y1007 + Y1008) Antibody detects endogenous levels of total Phospho-JAK2 (Y1007 + Y1008)

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB 1:500~1:2000 IHC 1:50~1:200 ICC 1:50~1:200 IP 1:50 FC 1:30

Mole Mass:130kDa

Location:Cell projection > Lamellipodium;

Concentration:

Sequence Similarity:Belongs to the SCAR/WAVE family.

Gene Id:

SwissProt ID:O60674

Unigene:

Nucleotide Accession:

Tissue specificity:Phospho-JAK2 (Y1007 + Y1008) Antibody detects endogenous levels of total Phospho-JAK2 (Y1007 + Y1008)

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Background:This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.