Anti-Phospho-SIRT1 (S47) Rabbit pAb
- 100ug (NP21354) Please inquiry
Antibody type:Primary antibody
Label:Unconjugated
Modification:Unmodification
Isotype:Rabbit IgG
Host:Rabbit
Application:WB,IHC,ICC/IF
Purify method:Affinity Chromatography
Species:Human
Gene Name:
Synonyms:hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2-like protein 1;
Gene Synonyms:
Gene Full Name:
Gene Infomation:Plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase at Threonine 35. In addition, the proline-directed kinases Cdk1, Cdk5, and mitogen-activated protein kinase (MAPK) mediate in vitro phosphorylation of IPP-1 at the phylogenetically conserved position Serine 67.
Antigen:A synthesized peptide derived from human Phospho-SIRT1 (S47)
Antigen Synonyms:
Clonality:Polyclonal antibody
Source:
Reaction:Phospho-SIRT1 (S47) Antibody detects endogenous levels of Phospho-SIRT1 (S47)
Form:Liquid
Tested Applications:
- Western blot (1:100 to 1:500)
- Immunofluorescence (1:50 to 1:400)
- Immunohistochemistry (1:200 to 1:500)
- Flow cytometry analysis (1:200 to 1:500)
- Enzyme-linked Immunosorbent Assay (1:100-1:5000)
Clone:
Dilution:WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
Mole Mass:110kDa
Location:
Concentration:
Sequence Similarity:Belongs to the protein phosphatase inhibitor 1 family.
Gene Id:
SwissProt ID:Q96EB6
Unigene:
Nucleotide Accession:
Tissue specificity:Phospho-SIRT1 (S47) Antibody detects endogenous levels of Phospho-SIRT1 (S47)
Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Buffer condition:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Background:This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.
Molar Function:
Western Blot:Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.