Anti-SH2D1A (C-term) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:WB

Purify method:Affinity purified

Species:Human

Gene Name:sh2d1a

Synonyms:SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP

Gene Synonyms:

Gene Full Name:

Gene Infomation:This gene encodes a protein that plays a major role in thebidirectional stimulation of T and B cells. This protein containsan SH2 domain and a short tail. It associates with the signalinglymphocyte-activation molecule, thereby acting as an inhibitor ofthis transmembrane protein by blocking the recruitment of theSH2-domain-containing signal-transduction molecule SHP-2 to itsdocking site. This protein can also bind to other related surfacemolecules that are expressed on activated T, B and NK cells,thereby modifying signal transduction pathways in these cells.Mutations in this gene cause lymphoproliferative syndrome X-linkedtype 1 or Duncan disease, a rare immunodeficiency characterized byextreme susceptibility to infection with Epstein-Barr virus, withsymptoms including severe mononucleosis and malignant lymphoma.Multiple transcript variants encoding different isoforms have beenfound for this gene.

Antigen:This SH2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the C-terminal region of human SH2D1A.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:RB41923

Dilution:WB::1:1000

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Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

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Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.