Anti-STAT3 Mouse mAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:IgG1

Host:Mouse

Application:WB

Purify method:Affinity purified

Species:Human,Mouse,Rat,Monkey,Hamster

Gene Name:stat3

Synonyms:APRF;HIES.

Gene Synonyms:1110034C02Rik;Acute Phase Response Factor;Acute-phase response factor;APRF;AW109958;DNA binding protein APRF;FLJ20882;HIES;MGC128731; MGC16063;MGC93551;Signal transducer and activator of transcription 3 (acute-phase response factor);Signal transducer and

Gene Full Name:

Gene Infomation:

Antigen:Purified recombinant human STAT3 protein fragments expressed in E.coli

Antigen Synonyms:

Clonality:Monclonal antibody

Source:Human

Reaction:This antibody detects endogenous levels of total STAT3 and does not cross-react with related proteins.

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:4C8-1C9-H8

Dilution:WB 1:1000

Mole Mass:88kDa

Location:Cytoplasm.Nucleus.Note: Shuttles between the nucleus and the cytoplasm.Translocated into the nucleus upon tyrosine phosphorylation and dimerization,in response to signaling by activated FGFR1,FGFR2,FGFR3 or FGFR4.Constitutive nuclear presence is independe

Concentration:

Sequence Similarity:Belongs to the transcription factor STAT family.Contains 1 SH2 domain.

Gene Id:6774

SwissProt ID:P40763

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Ascites containing with 0.03% Proclin300 and 50% glycerol.

Background:Signal transducer and transcription activator that mediates cellular responses to interleukins,KITLG/SCF and other growth factors.May mediate cellular responses to activated FGFR1,FGFR2,FGFR3 and FGFR4.Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.Activated by IL31 through IL31RA.Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G by similarity.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.