Anti-TBLR1 Mouse mAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:Unmodification

Isotype:IgG1

Host:Mouse

Application:WB,IHC,ICC

Purify method:Affinity purified

Species:Human,Mouse

Gene Name:tbl1xr1

Synonyms:C21; DC42; IRA1; TBLR1

Gene Synonyms:C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1-

Gene Full Name:

Gene Infomation:

Antigen:Purified recombinant human TBLR1 protein fragments expressed in E.coli.

Antigen Synonyms:

Clonality:Monclonal antibody

Source:Human

Reaction:This antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins.

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:4F3-A8-D9

Dilution:WB 1:1000,ICC 1:200,IHC 1:500~1:1000

Mole Mass:60kDa

Location:Nucleus

Concentration:

Sequence Similarity:Belongs to the WD repeat EBI family._x000D_Contains 1 F-box-like domain._x000D_Contains 1 LisH domain._x000D_Contains 8 WD repeats

Gene Id:79718

SwissProt ID:Q9BZK7

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Buffer condition:Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4 150 mM NaCl) with 0.02% sodium azide 50% glycerol

Background:This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.