Anti-TFE3 (N-term) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:WB,IF

Purify method:Affinity purified

Species:Human,Mouse

Gene Name:

Synonyms:Transcription factor E3, Class E basic helix-loop-helix protein 33, bHLHe33, TFE3, BHLHE33

Gene Synonyms:

Gene Full Name:

Gene Infomation:The microphthalmia transcription factor/transcriptionfactor E (MITF-TFE) family of basic helix-loop-helix leucine zipper(bHLH-Zip) transcription factors includes four family members:MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this geneactivates transcription through binding to the muE3 motif of theimmunoglobulin heavy-chain enhancer. The TFEC protein formsheterodimers with the TEF3 protein and inhibits TFE3-dependenttranscription activation. The TEF3 protein interacts withtranscription regulators such as E2F3, SMAD3, and LEF-1, and isinvolved in TGF-beta-induced transcription, playing important rolesin cell growth, proliferation, and osteoclast and macrophagedifferentiation. The TFE3 protein also activates hepatic IRS-2gene, and induces hexokinase II (HK2) and insulin-induced gene 1(INSIG1); it participates in insulin signaling and could be atherapeutic target for diabetes. This gene is also involved inchromosomal translocations, resulting in different fusion geneproducts in papillary renal cell carcinomas and alveolar soft partsarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO(p54nrb)-TFE3 and ASPL-TFE3.

Antigen:This TFE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TFE3.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:

Dilution:WB::1:2000ICC::1:10~50

Mole Mass:

Location:

Concentration:

Sequence Similarity:

Gene Id:

SwissProt ID:

Unigene:

Nucleotide Accession:

Tissue specificity:

Storage:

Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

Molar Function:

Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.