Anti-WAS (Center) Rabbit pAb

Antibody type:Primary antibody

Label:Unconjugated

Modification:

Isotype:Rabbit Ig

Host:Rabbit

Application:WB

Purify method:Affinity purified

Species:Human

Gene Name:was

Synonyms:Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2

Gene Synonyms:

Gene Full Name:

Gene Infomation:The Wiskott-Aldrich syndrome (WAS) family of proteinsshare similar domain structure, and are involved in transduction ofsignals from receptors on the cell surface to the actincytoskeleton.The presence of a number of different motifssuggests that they are regulated by a number of different stimuli,and interact with multiple proteins.Recent studies havedemonstrated that these proteins, directly or indirectly, associatewith the small GTPase, Cdc42, known to regulate formation of actinfilaments, and the cytoskeletal organizing complex, Arp2/3.Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessivedisease characterized by immune dysregulation andmicrothrombocytopenia, and is caused by mutations in the WAS gene.The WAS gene product is a cytoplasmic protein, expressedexclusively in hematopoietic cells, which show signalling andcytoskeletal abnormalities in WAS patients.A transcript variantarising as a result of alternative promoter usage, and containing adifferent 5' UTR sequence, has been described, however, itsfull-length nature is not known.

Antigen:This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human WAS.

Antigen Synonyms:

Clonality:Polyclonal antibody

Source:HUMAN

Reaction:

Form:Liquid

Tested Applications:

• Western blot (1:100 to 1:500)
• Immunofluorescence (1:50 to 1:400)
• Immunohistochemistry (1:200 to 1:500)
• Flow cytometry analysis (1:200 to 1:500)
• Enzyme-linked Immunosorbent Assay (1:100-1:5000)

Note: Users are strongly advised to determine the optimal dilution of antibody to use for their specific applications.

Clone:RB40707

Dilution:WB::1:1000

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Buffer condition:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Background:

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Western Blot: 

Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Storage: Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.