Canine FGF12 Protein
FGF12
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| Catalog Number | P70100-DNAE |
|---|---|
| Organism Species | Canine |
| Host | E. coli |
| Synonyms | FGF12 |
| Molecular Weight | The recombinant canine FGF12 comprises 181 amino acids and has a predicted molecular mass of 20.4 kDa. The apparent molecular mass of the protein is approximately 20 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the canine FGF12 (Glu2-Thr181) was expressed with a N-terminal Met. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Growth Factor & Receptor |Fibroblast Growth Factor (FGF) & Receptor |Fibroblast Growth Factor (FGF) | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. The specific function of FGF12 gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Reference |