Canine IL22RA1 / IL22R Protein (Fc Tag)
IL22RA1
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| Catalog Number | P70083-D02H |
|---|---|
| Organism Species | Canine |
| Host | Human Cells |
| Synonyms | IL22RA1 |
| Molecular Weight | The recombinant canine IL22RA1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 453 amino acids and has a predicted molecular mass of 51.2 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Ala 15 |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-Thr226) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Protein Trafficking |Vesicle Transport |Adapters |Transmembrane | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. |
| Reference |