Canine KIM-1 / TIM1 / HAVCR1 Protein (His Tag)
HAVCR1
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| Catalog Number | P70001-D07H |
|---|---|
| Organism Species | Canine |
| Host | Human Cells |
| Synonyms | HAVCR1 |
| Molecular Weight | The recombinant canine HAVCR1 consists of 156 amino acids and has a calculated molecular mass of 17.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 35-40 kDa due to glycosylation. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 96 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of canine HAVCR1 (XP_854888.1) (Tyr 21-Ser 160) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Immunology |Adaptive Immunity |Costimulation & Costimulatory Molecule |Other Costimulatory Molecules |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling. |
| Reference |