Cynomolgus CD86 / B7-2 Protein (Fc Tag)
CD86
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| Catalog Number | P90270-C02H |
|---|---|
| Organism Species | Cynomolgus |
| Host | Human Cells |
| Synonyms | CD86 |
| Molecular Weight | The recombinant cynomolgus CD86 is a disulfide-linked homodimer. The reduced monomer comprises 461 amino acids and has a calculated molecular mass of 52.2 KDa.The apparent molecular mass of the protein is approximately 76-86 and 34 KDa respectively in SDS-PAGE. |
| predicted N | Leu 20 |
| SDS-PAGE |  |
| Purity | (87.0+5.3) % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the cynomolgus CD86 (Q9BDM4) (Met1-His239) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Adaptive Immunity |Regulatory T Cells |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy. |
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