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Cynomolgus FGF21 / Fibroblast Growth Factor 21 Protein (His Tag)

FGF21,Fibroblast Growth Factor 21

Catalog Number P90843-C08H
Organism Species Cynomolgus
Host Human Cells
Synonyms FGF21,Fibroblast Growth Factor 21
Molecular Weight The recombinant cynomolgus FGF21 consists 192 amino acids and predicts a molecular mass of 20.9 kDa.
predicted N His 29
SDS-PAGE
Purity > 95 % as determined by SDS-PAGE.
Protein Construction A DNA sequence encoding the cynomolgus FGF21 (Met1-Ser209) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area Developmental Biology |Morphogenesis |Fibroblast Growth Factor (FGF) & Receptor |Fibroblast Growth Factor (FGF)
Formulation Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Reference
  • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
  • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
  • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.