Cynomolgus Hemojuvelin / HFE2 Protein (His Tag)
HFE2
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| Catalog Number | P90061-C08B |
|---|---|
| Organism Species | Cynomolgus |
| Host | Baculovirus-Insect Cells |
| Synonyms | HFE2 |
| Molecular Weight | The recombinant cynomolgus HFE2 comprises 376 amino acids and has a calculated molecular mass of 40.2 KDa. The apparent molecular mass of the protein is approximately 32 KDa in SDS-PAGE. |
| predicted N | Gln 36 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the cynomolgus HFE2 (EHH15137.1) (Met1-Ser400) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Developmental Biology |Metabolism |Pathways and Processes |Vitamins / minerals |
| Formulation | Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH). |
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