Cynomolgus LFA-3 / CD58 Protein (His Tag)
CD58,LFA3
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| Catalog Number | P90190-C08H |
|---|---|
| Organism Species | Cynomolgus |
| Host | Human Cells |
| Synonyms | CD58,LFA3 |
| Molecular Weight | The recombinant cynomolgus CD58 comprises 198 amino acids and has a calculated molecular mass of 23 KDa. The apparent molecular mass of it is approximately 38-42 KDa in SDS-PAGE under reducing conditions. |
| predicted N | Ile 29 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the cynomolgus CD58 (F7HQR6) (Met1-Arg215) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD58-His at 10 μg/ml (100 μl/well) can bind Cynomolgus CD2-Fc (P90300-C02H), The EC50 of Cynomolgus CD2-Fc (P90300-C02H) is 0.06-0.14 μg/ml. |
| Research Area | Immunology |Innate Immunity |Monocytes/Macrophages |Co-stimulatory Molecules |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. |
| Reference |