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Cynomolgus TALLA-1 / TSPAN7 Protein (Fc Tag)

TSPAN7

Catalog Number P90243-C04H
Organism Species Cynomolgus
Host Human Cells
Synonyms TSPAN7
Molecular Weight The recombinant cynomolgus TSPAN7 is a disulfide-linked homodimer. The reduced monomer comprises 337 amino acids and has a calculated molecular mass of 38.2 KDa. The apparent molecular mass of it is approximately 45-49 KDa respectively in SDS-PAGE.
predicted N Asp
SDS-PAGE
Purity (92.7 %+5.7) % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the cynomolgus TSPAN7 (Q4R5A3) (Arg113-Met213) was expressed with the Fc region of mouse IgG1 at the N-terminus.
Bio-activity
Research Area Signaling |Signal Transduction |Metabolism |Pathways and Processes |Metabolic signaling pathways |Amino acid metabolism |
Formulation Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins.
Reference
  • Berditchevski F. 2002, J Cell Sci. 114 (23): 4143-51.
  • Castellví-Bel S. et al., 2001, Mol Genet Metab. 72 (2): 104-8.
  • Abidi FE. et al., 2002, J Med Genet. 39 (6): 430-3.