Cynomolgus XEDAR / EDA2R Protein (Fc Tag)
EDA2R, TNFRSF27, XEDAR
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| Catalog Number | P90110-C02H |
|---|---|
| Organism Species | Cynomolgus |
| Host | Human Cells |
| Synonyms | EDA2R, TNFRSF27, XEDAR |
| Molecular Weight | The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377 amino acids and has a calculated molecular mass of 42.1 KDa.The apparent molecular mass of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | (60.3+19.2+15) % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the cynomolgus EDA2R (NP_001180396.1) (Met1-Glu136) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |Apoptosis |Intracellular |NF-kB (NFkB) Pathway |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR). |
| Reference |