Danio rerio (zebrafish) BMP-2 / BMP2A Protein
BMP2A
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| Catalog Number | P63003-ZNAE |
|---|---|
| Organism Species | Danio rerio (zebrafish) |
| Host | E. coli |
| Synonyms | BMP2A |
| Molecular Weight | The recombinant zebrafish BMP2A consists of 116 amino acids and has a calculated molecular mass of 13.2 kDa. It migrates as an 13 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the zebrafish BMP2A (B3DI86) (Gln272-Arg386) was expressed and purified with an initial Met. |
| Bio-activity | Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.5-3 μg/mL. |
| Research Area | Immunology |Signal Transduction |Cytoskeleton / ECM |Extracellular Matrix |Structures |Bone | |
| Formulation | Lyophilized from sterile 30mM HAC, pH 3.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma. |
| Reference |