Human AFP / alpha-fetoprotein Protein (His Tag)
AFPD,Alpha-fetoprotein,FETA,HPAFP
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| Catalog Number | P12177-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | AFPD,Alpha-fetoprotein,FETA,HPAFP |
| Molecular Weight | The recombinant human AFP consists of 602 amino acids and has a predicted molecular mass of 67.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhAFP is approximately 65 kDa. |
| predicted N | Arg 19 |
| SDS-PAGE |  |
| Purity | > 97 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human AFP (P02771) (Met 1-Val 609) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Oncoprotein & suppressor & biomarker |Tumor suppressor |Other in Tumor suppressor |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin. AFP is a glycoprotein of 591 amino acids and a carbohydrate moiety. AFP is one of the several embryo-specific proteins and is a dominant serum protein as early in human embryonic life as one month, when albumin and transferrin are present in relatively small amounts. It is first synthesized in the human by the yolk sac and liver(1-2 months) and subsequently predominantly in the liver. A small amount of AFP is produced by the GI tract of the human conceptus. It has been proved that AFP may reappear in the serum in elevated amounts in adult life in association with normal restorative processes and with malignant growth. Alpha-fetoprotein (AFP) is a specific marker for hepatocellular carcinoma (HCC), teratoblastomas, and neural tube defect (NTD). |
| Reference |