Human AKR1C2 Protein (His Tag)
AKR1C2, DDH2
- 100ug (NPP1052) Please inquiry
| Catalog Number | P14175-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | AKR1C2, DDH2 |
| Molecular Weight | The recombinant human AKR1C2 consists of 338 amino acids and predicts a molecular mass of 38.6 KDa. It migrates as an approximately 37 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human AKR1C2 (P52895-1) (Met1-Tyr323) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Metabolism |Pathways and Processes |Metabolic signaling pathways |Drug metabolism | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for AKR1C2 gene. |
| Reference |