Human ALDOB / Aldolase B Protein GST Tag

ALDB,ALDO2

Catalog Number	P13207-H09E
Organism Species	Human
Host	E. coli
Synonyms	ALDB,ALDO2
Molecular Weight	The recombinant human ALDOB/GST chimera consists of 597 amino acids and has a predicted molecular mass of 66.5 kDa. It migrates as an approxiamtely 60 KDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 88 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human ALDOB (P05062) (Ala 2-Tyr 364) was fused with the GST tag at the N-terminus.
Bio-activity
Research Area	Cancer \|Cancer Metabolism \|Metabolic signaling \|Metabolism of carbohydrate
Formulation	Lyophilized from sterile PBS, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Cox TM. (1994) Aldolase B and fructose intolerance. FASEB J. 8(1): 62-71. Malay AD, et al. (2005) Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance. J Mol Biol. 347(1): 135-44. Susan PP, et al. (2001) Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport. J Cell Physiol. 187(1): 48-58.