Human Angiopoietin 4 / ANG4 / ANGPT4 Protein (Fc Tag)

AGP4,ANG-3,ANG4

• 100ug (NPP1062) Please inquiry

Catalog Number	P10293-H01H
Organism Species	Human
Host	Human Cells
Synonyms	AGP4,ANG-3,ANG4
Molecular Weight	The recombinant human ANGPT4/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 483 amino acids and has a calculated molecular mass of 53.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhANGPT4/Fc monomer is approximately 66 kDa due to the glycosylation.
predicted N	Glu
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human ANGPT4 (Q9Y264) C-terminal fragment (Met 282-Ile 503) was fused with the Fc region of human IgG1 at the N-terminus.
Bio-activity
Research Area	Cancer |Signal transduction |Metabolism |Pathways and Processes |Metabolism processes |Apoptosis |
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Grosios K, et al. (1999) Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3?q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. Cytogenet. Cell Genet. 84 (1-2): 118-20. Yamakawa M, et al. (2004) Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. Am J Physiol Renal Physiol. 287 (4): 649-57. Oliner J, et al. (2004) Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell. 6 (5): 507-16.