Human B3GNT6 Protein (aa 44-384, His Tag)
B3Gn-T6,beta-1,3-Gn-T6,beta3Gn-T6,BGnT-6
- 100ug (NPP1921) Please inquiry
| Catalog Number | P13951-H07B |
|---|---|
| Organism Species | Human |
| Host | Baculovirus-Insect Cells |
| Synonyms | B3Gn-T6,beta-1,3-Gn-T6,beta3Gn-T6,BGnT-6 |
| Molecular Weight | The recombinant human B3GNT6 consists of 357 amino acids and has a calculated molecular mass of 40 kDa. The recombinant protein migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human B3GNT6 (Gln44-Ser384) was fused with a polyhistide tag at the N-terminus. |
| Bio-activity | |
| Research Area | Developmental Biology |Metabolism |Types of disease |Metabolism in Cancer |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | B3GNT6 belongs to the glycosyltransferase 31 family. B3GNT6 play s an important role in the synthesis of mucin-type O-glycans in digestive organs. It catalyzes the transfer of GlcNAc from UDP-GlcNAc to GalNAcalpha1-Ser/Thr (Tn antigen) to form the core 3 structure (GlcNAcbeta1-3GalNAcalpha1-Ser/Thr). Core 3 structure exists in O-glycan which is an important precursor in the biosynthesis of mucin-type glycoproteins. Loss of core 3 could lead to the production of secreted mucins, then bacteria would be inefficiently cleared from the system, and chronic inflammation would be developed, which eventually would result in development of cancer. B3GNT6 gene is a tumor suppressor gene. |
| Reference |