Human B7-H5 / Gi24 / VISTA Protein (ECD, Fc Tag)
B7-H5,B7H5,DD1alpha,GI24,PP2135,SISP1,VISTA
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| Catalog Number | P13482-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | B7-H5,B7H5,DD1alpha,GI24,PP2135,SISP1,VISTA |
| Molecular Weight | The recombinant human C10orf54 consists 400 amino acids and predicts a molecular mass of 44.9 kDa. |
| predicted N | Phe 33 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the human C10orf54 (AAH20568.1) (Met1-Ala194) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Innate Immunity |Monocytes/Macrophages |Co-stimulatory Molecules |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. |
| Reference |