Human BCL2L11 / Bim Protein (His Tag)
BAM,BIM,BOD
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| Catalog Number | P13816-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | BAM,BIM,BOD |
| Molecular Weight | The recombinant human BCL2L11 consists of 130 amino acids and predicts a molecular mass of 15 KDa. It migrates as an approximately 16-20 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human BCL2L11 (NP_612815.1) (Ala2-Arg120) was expressed with a polyhistide tag at the N-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Cellular Senescence and Pathways in Aging |Apoptosis |
| Formulation | Lyophilized from sterile 50mM Tris, 10% Glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymocyte-negative selection. |
| Reference |