Call Now

Human BIN1 / Amphiphysin-II Protein (His Tag)

AMPH2,AMPHL,SH3P9

Catalog Number P11361-H07E
Organism Species Human
Host E. coli
Synonyms AMPH2,AMPHL,SH3P9
Molecular Weight The recombinant human BIN1 comprises 439 amino acids and has a predicted molecular mass of 49.3 kDa. It migrates as an approximately 52 kDa band in SDS-PAGE under reducing conditions.
predicted N Met
SDS-PAGE
Purity > 85 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the human BIN1 isoform BIN1-13 (O00499-10) (Met 1-Pro 424) was expressed, with a polyhistidine tag at the N-terminus.
Bio-activity
Research Area Cancer |Oncoprotein & suppressor & biomarker |Tumor biomarker |Tumor Suppressor
Formulation Lyophilized from sterile 20mM Tris, 10% glycerol, 1mM DDT, pH 8.0
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference
  • Eisenman RN. (2001) Deconstructing Myc. Genes & Dev. 15: 2023-30
  • Bouchard C, et al. (1998) Control of cell proliferation by Myc. Trends in Cell Biology. 8(5): 202-6.
  • Sakamurol D, et al. (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nature Genetics. 14: 69-77.