Human BNIP3L Protein

BNIP3a,NIX

Catalog Number	P12488-HNCE
Organism Species	Human
Host	E. coli
Synonyms	BNIP3a,NIX
Molecular Weight	The recombinant human BNIP3L consists of 186 amino acids and has a calculated molecular mass of 20.4 kDa. It migrates as an approximately 36 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 88 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human BNIP3L (Q7Z465-1) (Ser 2-Lys 187) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
Bio-activity
Research Area	Cancer \|Signal transduction \|Metabolism \|Pathways and Processes \|Metabolism processes \|Apoptosis \|
Formulation	Lyophilized from sterile 50mM Tris, 150mM NaCl, 1mM DTT, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Imazu T, et al. (1999) Bcl-2 / E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2 / Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene. 18(32): 4523-9. Sun JL, et al. (2004) Expression and structure of BNIP3L in lung cancer. Ai Zheng. 23(1): 8-14.