Human Biglycan / BGN Protein (His Tag)

DSPG1,PG-S1,PGI,SLRR1A

Catalog Number	P10447-H08H
Organism Species	Human
Host	Human Cells
Synonyms	DSPG1,PG-S1,PGI,SLRR1A
Molecular Weight	The recombinant human BGN consists of 342 amino acids and predicts a molecular mass of 38.7 kDa.
predicted N	Asp 38
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE.
Protein Construction	A DNA sequence encoding the human BGN (NP_001702.1) (Asp38-Lys368) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Developmental Biology \|Embryogenesis \|Germ Layer Formation \|Mesoderm Marker
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.
Reference