Human CALU / Calumenin Protein (His Tag)
CALU
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| Catalog Number | P13486-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CALU |
| Molecular Weight | The recombinant human CALU consists of 303 amino acids and predicts a molecular mass of 35.9 KDa. It migrates as an approximately 46-52 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Lys 20 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CALU (O43852-1) (Met1-Arg311) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Calumenin belongs to the CREC family. It contains 6 EF-hand domains. Calumenin is expressed in skeletal muscle (at protein level). Calumenin interacts with GGCX and RYR1 in the presence of calcium ions, but not in the presence of EDTA. Calumenin is Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. It seems to inhibit gamma-carboxylase GGCX. Calumenin also binds 7 calcium ions with a low affinity and may modulate calcium release from the sarcoplasmic reticulum. |
| Reference |