Human CCDC134 Protein (His Tag)
FLJ22349, MGC21013, dJ821D11.3
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| Catalog Number | P13168-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | FLJ22349, MGC21013, dJ821D11.3 |
| Molecular Weight | The secreted recombinant human CCDC134 consists of 218 amino acids and has a predicted molecular mass of 25.7 kDa. The apparent molecular mass of rhCCDC134 is approximately 33 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Thr 23 |
| SDS-PAGE |  |
| Purity | > 98 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CCDC134 (Q9H6E4) (Met 1-Leu 229) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Signaling Pathway |Representative pathway |MAPK singaling Pathway |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Human coiled-coil domain containing 134 (CCDC134) is a 229 amino acids secretory protein. Coiled-coil domain is a motif in which alpha-helix are coiled together. It has been found in many types of proteins, including transcription factors, intermediate filaments and certain tRNA synthetases. Many proteins containing such motif CCDC134 are involved in important biological functions. CCDC134 is also considered as a novel human MAPK-regulating protein that can inhibit the MAPK pathway. This protein significantly inhibite Elk1 transcriptional activity. The coiled-coil domain is a ubiquitous protein motif that is often involved in oligomerization. |
| Reference |