Human CD14 Protein (His Tag)
CD14 antigen,monocyte differentiation antigen CD14
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| Catalog Number | P10073-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD14 antigen,monocyte differentiation antigen CD14 |
| Molecular Weight | The secreted recombinant human CD14 consists of 336 amino acids and has a predicted molecular mass of 36.5 kDa. The apparent molecular mass of rhCD14 is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Thr 20 |
| SDS-PAGE |  |
| Purity | > 97 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human CD14 (NP_000582.1) (Met 1-Met 344) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Inflammation / Inflammatory Mediator |Cells Involved in Inflammation |Myeloid-derived Suppressor Cells (MDSC) |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 14 (CD14) is a member of the CD system. It takes its name from its inclusion in the CD molecule surface marker proteins. CD14 exists in two forms: a form anchored into the membrane or a soluble form. CD14 was found expressed in macrophages, neutrophil granulocyte and dendritic cells. The major function is serve as a co-receptor (along with TLR4 and MD-2) for the bacterial lipopolysaccharide (LPS) and other pathogen-associated molecular patterns. |
| Reference |