Human CD200R1 Protein (His & Fc Tag)
CD200R,HCRTR2,MOX2R,OX2R
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| Catalog Number | P11218-H03H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD200R,HCRTR2,MOX2R,OX2R |
| Molecular Weight | The secreted recombinant human CD200R1/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 488 amino acids and has a predicted molecular mass of 54.9 kDa. As a result of glycosylation, rh CD200R1/Fc monomer migrates as an approximately 90-100 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Ala 27 |
| SDS-PAGE |  |
| Purity | > 94 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CD200R1 (AAI43394.1) extracellular doamin (Met 1-Leu 266) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Bio-activity | Measured by its binding ability in a functional ELISA . Immobilized recombinant human CD200 at 1 μg/ml (100ul/well) can bind human CD200R1 / Fc Chimera with a linear range of 0.12-16 ng/ml . |
| Research Area | Immunology |Cluster of Differentiation (CD) |Granulocyte CD Antigen |CD Antigen (Neutrophils) |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 is a receptor for the OX-2 membrane glycoprotein. The receptor-substrate interaction may serve as a myeloid downregulatory signal. |
| Reference |