Human CD24 Protein (Fc Tag)
CD24A,FLJ22950,FLJ43543,MGC75043
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| Catalog Number | P11030-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD24A,FLJ22950,FLJ43543,MGC75043 |
| Molecular Weight | The recombinant human CD24/Fc is a disulfide-linked homodimer. The reduced monomer consists of 274 amino acids and has a predicted molecular mass of 30 kDa. As a result of glycosylation, rh CD24/Fc monomer migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Ser 27 |
| SDS-PAGE |  |
| Purity | > 92 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CD24 (NP_037362.1) (Met 1-Gly 59) was fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Adaptive Immunity |B Cell |B Cell CD Antigen |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 24, also known as signal transducer CD24 or heat stable antigen CD24 (HSA), is a mucin-type glycosylphosphatidylinositol-linked glycoprotein expressed on the surface of B-cells, differentiating neuroblasts and many tumors. It is involved in molecular adhesion and metastatic tumor spread and serve as a normal receptor for P-selectin. The CD24 / P-selectin pathway could be important in dissimenating of tumor cells by facilitating the interaction with platelet and endothelial cells. It has also been considered as a tumor marker. High rate of CD24 expressions have been found in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer. |
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